Energy Metabolism in the Fasted State – [Cahill’s Research]

Energy Metabolism in the Fasted State - [Cahill's Research]

Prolonged fasting has received a lot of attention from the scientific community, historically speaking. And it’s still on the radar today because it may elicit powerful positive effects in many subjects (not for everyone). The sad part is that it fails to become popular as a practice possible because there are little ‘stakes’ (skin in the game) to promote it – it’s not financially feasible to tell someone not to eat anything or not to consume this weight loss pill or that longevity boosting pill. Hopefully, you get the point.

My Blood Work #4 – March 2016 – [Variations]

My Blood Work #4 - March 2016 - [Variations]


The last time I posted about my blood work was in Nov. 2015. Here is my March 2016 update:

The Five Stages of Fasting – Dr. Nikolayev [Russian Case Studies]

The Five Stages of Fasting - Dr. Nikolayev [Russian Case Studies]


During a visit at the local library I stumbled upon a book on fasting (written in Romanian). I do most of my reading on my tablet, for convenience. Trying to locate the book on Amazon Kindle returned an empty query. To my surprise, the book was not available/translated to English. It was only available in French. So, I bought the book – the physical copy.

I’m not sorry about the investment I made. Many concepts and ideas from this book are also detailed in my book Periodic Fasting. This is great because when some of my fellow Romanians will ask me to translate my book, I could simply guide them to book of Lestrade, which is already available in Romanian.

Furthermore, Thierry Lestrade obtained first-person access to research and experiments conducted by Russian scientists and doctors with regards to therapeutic fasting. Much of this research will be lost in the archives of Russian institutes as they have not (and most likely will not) been translated into other languages, unless we can do something about it.

In this entry I will describe the five stages of prolonged water fasting, as it has been widely used in the practice of Dr. Yuri Nikolayev, the Director of the Fasting Clinic of The Moscow Institute of Psychiatry for many years.

He claimed to have successfully treated more than 7,000 patients (as of 1972) suffering from neuro-psychiatric conditions by using therapeutic fasting. The average duration of a fast would be 30 days. He probably oversaw the experience of more than 10,000 patients because in 1972 he was only at the heights of his career.

The Metabolic Features of Keto-Adapted (20 Months) Ultra Athletes [Comparative Study]

The Metabolic Features of Keto-Adapted (20 Months) Ultra Athletes - Study Timeline


First well designed and conducted study of keto-adapted athletes? Let’s see…

Many think that keto-adaptation is the result of 2-3 weeks of ketosis. Simply put, that is delusional.

I encourage you not to believe me. Listen to Barry Murray who works with fat adapted athletes and who observed how the process could take from at least 6 months to more than 2 years, widely varying between individuals. And, I’ve seen it on myself.

I’ve been using ketosis (the metabolic state where fat becomes the primary source of fuel) since October 2013. I’ve been in ketosis 98% of the time. My personal approach does not resemble the fat-laden ketogenic diet that’s preached out there; one of the focal points of my strategy is micronutrient optimization.

Ketosis + IF – How Many Kcals to Consume [Situational]

Ketosis + IF - How Many Kcals to Consume


This write-up is part of a series that adds insight to the combo strategy of ketosis and intermittent fasting (IF) that I’ve been using over the past two years. In this specific post I’m providing a rationale for the amount of calories you should/may consume when switching to ketosis and IF and when you come from a different nutritional background – a higher carbohydrate diet with/without IF, a keto diet without IF, or any other protocol. Here we go…

Blood Work #3 – November 2015 [Consistency]

Blood Work #3 - November 2015 - [Consistency]

Last time I posted about my blood tests was in July 2015. And here are the results that I got from my most recent blood tests:

9 ways I keep my Testosterone Levels High – Test of Time

9 Ways I Keep my Testosterone Levels High - Test of Time


I began testing my testosterone levels a couple of months after starting with ketosis (the metabolic state where fat becomes the primary source of energy). It was March 2014 and my levels ~400 ng/dL. That’s average to low for a person my age.

I suspect my pre-ketosis levels were even lower because from what I’ve researched, if well-formulated, a ketogenic diet can improve testosterone levels. In a matter of months, I’ve been able to raise my levels to ~ 850ng/dL and they’ve been mostly constant ever since. See more here.

I wrote about this experiment in detail in my book T-R(x) – The Testosterone Protocol, but I want to re-emphasize the 9 major interventions I made to improve my T levels.

The Minnesota Starvation Experiment – The Other Ancel Keys

The Minnesota Starvation Experiment - The Other Ancel Keys


We live in a world supersaturated with food. Eating every couple of hours is the norm for most folks. No wonder there are more people dieing from food triggered diseases (diabetes T2, obesity, other disease of the metabolic syndrome, etc) than of starvation.

Food saturation became reality only in past few decades. In fact, one of the checkpoints of food scarcity, if I may, of the 20th century is represented by the years during and immediate to WWII.

During the 1940s Ancel Keys, a scientist with degrees in economics, political science and zoology, started conducting experiments in human physiology. He was studying semi-starvation to gain “insight into the physical and psychologic effects of semistarvation and the problem of refeeding civilians who had been starved during the war” [1]. It was for a good cause from what I see.

Ancel Keys and his colleagues wanted to determine efficient strategies for the victims of famine of WWII. Their studies and experiments ended in two voluminous books of 1,400 pages [2].

Lactate as Brain Fuel – Experiments and Implications

Lactate as Brain Fuel - Experiments and Implications


I follow the work of Dr. Rhonda Patrick. She’s a very knowledgeable researcher. She’s been the mentee of Prof. Bruce Ames, who’s been doing science experiments for more than 60 years.

During one of her interviews, Dr. Patrick invited Dr. George Brooks, who researches Exercise Physiology and Metabolism at U.C. Berkeley, to talk about lactate as brain fuel. To better understand this write-up, I’d recommend listening to the interview.

Few people are aware that lactate can serve as efficient fuel for the brain, especially in the situations of fasting, strenuous exercise or traumatic brain injury, to name a few. While listening to the talk between Dr. Patrick and Dr. Brooks I made the connection. I remembered the mental clarity that I always get after a hard weight lifting workout in a fasted state.

Fuel Metabolism in Prolonged Fasting – What Happens when You Stop Eating

Fuel Metabolism in Prolonged Fasting - What Happens when You Stop Eating - 1


Much controversy/mysticism has gathered around the idea of fasting, especially for prolonged fasting. Folks seem to regurgitate the same obsolete messages that have been promoted by fitness paranoids for decades (i.e. fasting makes you lose lean mass). Yet, the science is still there. It has always been. But it’s not been available to the ignorant eye.

George Cahill was one of the leading fasting/starvation researchers. His experiments have been widely admired and appreciated in the literature. I’m one of his fans. In the following lines you’re about to read an excerpt from my book on Periodic Fasting. It’s about energy metabolism as you stop consuming food.

From the book (Chapter 4):

So, for one to start efficiently doing prolonged fasting and intermittent fasting, I will briefly talk about their physiologic implications (in simple terms) as well as some strategies to reduce the first negative symptoms that may appear. This will serve as a basis to understand the upcoming chapters, where I will go deeper into the molecular mechanisms that occur as one stops consuming anything but water for at least 18 hours. Intermittent fasting can be so much fun, especially when you add different rewarding mechanisms to it (such as black coffee unsweetened or sweetened with some stevia, tea, and others).

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