LPL – An Important Key of the Metabolic Equation of Fat

LPL - Lipoprotein Lipase


Lipoprotein lipase (LPL) is an enzyme playing an important role in lipid metabolism. Its purpose is to facilitate the transport of fatty acids inside the cells throughout your body, such as muscle, adipose, and heart tissue to name a few.

What does it do?

Say you eat a meal that has some fat in it. Once the fatty acids get into your intestines, they are packaged into chylomicrons (a lipoprotein) as triglycerides and they are transported to different parts of the body, such as: to the liver, to the cardiac tissue, to muscle tissue, to adipocytes, etc.

Before going further I would like to emphasize on the fact that I think there is not one single enzyme or hormone that should be considered decisive by itself, but that things should always be put into perspective so that the bigger picture is visible. I discuss about LPL, leptin, grehlin, insulin and other factors of this equation in the upcoming book (see the end of the article).

Flow – The State of Perfect, Pure Happiness

Flow - The State of Perfect, Pure Happiness


Have you ever felt that you’re in the right place, with the right person and at the right time? It is the moment when you are not projecting yourself into future and you’re not constantly digging up the past.

It is the moment of pure happiness. You let go of everything. You just feel. You are living the present moment and it feels perfect. Eckhart Tolle talks about it. There are various books written on it. Some call it flow, the state of pure happiness. I have felt it several times throughout my life, and often times recently. I’m gonna talk about these experiences.

A Distant Exotic Location

It all started with a picture. A burning desire…

More than a year ago one of my Facebook friends (a female model) posted a picture from a beautiful island in Thailand. I was fascinated. Something inside arose an extreme passion. It was like a fire burning from within, making me insanely eager to get there. My mirror neurons wire firing as fuck…

Hibernation – How Bears can go without Food and Water for Months

Hibernation - How Bears can go without Food and Water for Months


I was reading on lipid metabolism the other day when I got to a very interesting “fact box” in Lehninger Principles of Biochemistry. The title was “Fat Bears Carry out Beta Oxidation in Their Sleep”.

It describes that many animals depend on their fat storage for energy production when they are in hibernation and it says that one of the most pronounced adjustments of fat metabolism occurs in hibernating grizzly bears.

Did you know that grizzly bears are in hibernation for as long as 7 months per years?

Neuroplasticity – The Systematic Approach to a New You

Neuroplasticity - The Systematic Approach to a New You


Up until recently it was thought that if you were born with a certain mental heritage, you will not be able to change it ever. Researchers believed that your mind configuration is the same throughout your life, that the connections between your neurons are fixed and rigid.

This means that if you were born a shy person, you will be like that the rest of your life, or that if you do not have inclinations to math you cannot be a good scientist. Many people still believe these facts and still live their lives under these terms. There is no one to blame.

Recent research shows that these assumptions are not correct anymore. In fact, the existing neuronal connections can be untied, while other connections can be created. These neuronal connections that we are talking about are encoding different traits of character and different behaviors that you have.

Neuro what? Neuroplasticity…

These behaviors can be untaught, while other behaviors and habits can arise. The temperament of a person can be changed. With learning, repetition, and experience accumulation the shy can become the bold, while the fearful can learn how to efficiently attack his fears.

Energy Levels under Ketosis – Fats, Carbs, and ATP

Energy Levels in Ketosis - Fats, Carbs, and ATP


Ever since I started my ketogenic lifestyle I’ve been experiencing higher energy levels. Basically I have the same increased energy from the minute I wake up at ~7 A.M. up until I go to sleep at 2 A.M. at night. No post-prandial (after-meal) fatigue and no sleepiness during the day. It’s been quite amazing because during my entire life I was kind of suffering of moments of tiredness throughout the day.

As I began researching what happens inside the body under high-fat-very-low-carb nutrition, I wanted to know what could be the possible explanation of the higher energy levels. I’ve learned that carbohydrate metabolism yields lower amounts of ATP compared to beta-oxidation (fat metabolism).

Carbohydrate Metabolism

It basically starts with glycolysis which has the purpose of converting 1 molecule of glucose to two molecules of pyruvic acids (pyruvates). Glycolysis yields 4 ATPs, but it requires 2 ATPs to be completed, so the net gain of energy is 2 ATPs.

Expediency Factor – Why most of us Never get Anywhere

Expediency Factor - Why most of us Never get Anywhere


Yesterday I was watching a video of Brian Tracy shot a few decades ago. It’s pretty amazing what Youtube can do because I wanted to analyze the body posture of Brian from back then compared to what it is today. He expresses the same confidence he expressed in the past, that self-confidence that he talks most about.

However, this post is not about my virtual mentor, who I’m very thrilled of because I’ll be meeting Brian next week in a seminar he’s holding in a nearby city. The old video that I was watching was about 10 keys to personal power. It caught my full attention when he started talking about the expediency factor.

Expediency Factor and Failure

According to Brian Tracy, the major reason why people fail is because of the expediency factor, that is: we always tend to take the fastest and the easiest route to the things that we want. And that’s almost always the route to failure.

We do things by this rule: “Short-term gain for Long-term pain.” (B.T.)

Why we, the creatures of excellence, focus on what’s fun and easy rather than what’s more difficult and necessary?

I find that the expediency factor has a lot to do with the path of least resistance. It’s easier for us just to meet the minimum requirements in our daily jobs.

Lipogenesis and Ketosis – No Conversion of Carbohydrates to Fats in Ketogenic Diets

Lipogenesis and Ketosis - No Conversion of Carbs to Fats in Ketogenic Diets


While busting my head with Guyton’s Medical Physiology, I was very focused on the fat metabolism chapter. I was trying to grasp upon all the concepts and chemical processes that occur when something caught my attention.

It was: “failure to synthesize fats from carbohydrates in the absence of insulin“. I remember that context matters, which is why I fully engaged into seeing what it is all about. Guyton was describing the situation of diabetes mellitus saying that if insulin is not available, glucose cannot enter into cells efficiently.

This means there is a shortage of Acetyl-CoA and NADPH, both of which are needed to lipogenesis. Also, since there is little glucose available, there will be less of α-glycerophosphate which is also needed to create triglycerides (lipogenesis).

We know that you do not have to be diabetic (T1D in most of the cases) to have lower levels of insulin in your circulation, as well as little to no glucose inside your cells. Just limit the amount of carbohydrates you consume and this process of lipogenesis will not occur. But what is lipogenesis?

The Classics – Art and Science of Low-Carbohydrate Living – Phinney and Volek

IHMC - Phiney and Volek

To be honest, I first read The Art and Science of Low Carbohydrate Performance by Steven Phinney and Jeff Volek, which is about increasing your physical output while being under ketogenic nutrition. The book is quite good but it does not go into details with the science of very low carbohydrate nutrition. It’s a good read and it’s only 170+ pages.

I read it while starting my ketogenic experiment. I finished it quite quickly and I wanted to know more about the science behind it, which is why I started reading The Art and Science of Low Carbohydrate Living, written by the same two authors. This one has 315+ pages and it references 140 research studies.

They first tell us a little history lesson and talk about how Phinney researched the case of an explorer who lived only with fat and meat during a one year expedition to a very cold location.

Their book is divided into 5 sections and 21 chapters. They cover the perspective of low-carb nutrition, then they further into the physiology behind the program, then they talk about clinical applications of ketogenic diets, while the last section is covered by guests such as: Eric Kossoff, Jacqueline Eberstein, and Jimmy Moore.

I remember that I had a few questions that I couldn’t find answer to before reading this book. I wasn’t sure about the total-carb – net-carb concept. I learned that fibers do not spike insulin levels, which is why only net carbs matter. It can become tricky for a less-initiated persona who’s not able to hit ketosis (the special metabolic state).

The Real Purpose of Exercising – Kill Anxiety, Panic, and Depression

The Real Purpose of Exercising - Kill Anxiety, Panic, and Depression

Personal Beliefs

Not until long ago I was advocating that physical exercise is necessary in the process of weight-loss. I always believed in the calories-in versus calories-out dogma. But it’s more than that. Energy management and energy change within systems is far more complex than calories-in vs. calories-out.

What does this mean?

You can always hear in the media that you have to burn more calories than you consume if you wanna lose weight. And you do that by working-out and by eating less. It’s bullshit if you ask me and Gary Taubes.

It may work when you’re burning glucose as your primary source of fuel, but if you restrict food intake you’ll feel very cranky and energy depleted.

For example, a full hour on the treadmill can burn at most 500-600kcals. How does that translate into food?

It’s like 100g of chocolate. It’s like 200g of lean meat (cooked). It’s like 4 medium sized slices of bread. I find it very inefficient to live your life under this credo because you have to extenuate yourself in the gym every day.

Barbecue Coconut – Guilt-Free High-Fat Treat

Barbecue Coconut - Ketosis

You know that many specialists from the keto community say that coconut is one type of food that you can consume without restrictions (especially coconut oil and coconut milk). It is high in fat and very low in carbohydrates.

The benefits of consuming coconut are partly due to the fact that coconut is high in MCT (medium chain triglycerides) and it increases ketone bodies production.

Unlike other types of fatty acids (like long-chain triglycerides) they do not require carnitine to be transported through the mitochondrial membrane and they are readily available for energy production.

Anyway, I’ve also seen many people reporting gastro-intestinal distress after consuming too much pure MCTs. But we’re talking about coconuts here and not pure 100% MCT oil. So let’s not get far from the subject.

If you travel to Thailand and you’re eager to consume local foods that are in line with your high-fat nutrition, “BBQ coconut” is one of these foods. Here’s a video that shows how they prepare it.

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